Published in American Society for Clinical Pharmacology & Therapeutics
Authors: Edwin K. Silverman, M.D., Ph.D. and Joseph Loscalzo, M.D., Ph.D.
Although impressive advances have been made in determining the genetic and molecular causes of disease, treatment for many complex diseases remains inadequate. Despite compelling unmet medical needs and new insights into disease pathobiology, new drug approvals for complex diseases have stagnated. A new paradigm for drug development is needed, and key concepts from network medicine and systems pharmacology may be essential to this effort.