Clin Pharmacol Ther. Author manuscript; available in PMC 2013 January 15.
Published in final edited form as:
Clin Pharmacol Ther. 2013 January ; 93(1): 26–28. doi:10.1038/clpt.2012.207.
Authors: Edwin K. Silverman, M.D., Ph.D. and Joseph Loscalzo, M.D., Ph.D.
Although impressive advances have been made in determining the genetic and molecular causes of disease, treatment for many complex diseases remains inadequate. Despite compelling unmet medical needs and new insights into disease pathobiology, new drug approvals for complex diseases have stagnated. A new paradigm for drug development is needed, and key concepts from network medicine and systems pharmacology may be essential to this effort.