Drug discovery and development remains one of the most challenging and resource-intensive processes in modern medicine. With development timelines spanning 10-15 years and costs exceeding $1-3 billion per approved drug1, the need for more efficient target...
Uday Shankar Shanthamallu, Casey Kilpatrick, Alex Jones, Jonathan Rubin, Alif Saleh, Albert-László Barabási, Viatcheslav R. Akmaev, Susan Dina Ghiassian ABSTRACT Precision medicine’s potential to transform complex autoimmune-disease treatment is often challenged...
Shanthamallu, Uday Shankar ; Jones, Alexander ; Panés, Julián ; Corraliza Márquez, Ana Maria ; Salas, Azucena ; Akmaev, Slava ; Ghiassian, Susan Dina Background Non-response to TNF inhibitor (TNFi) therapies remains a challenge in UC/IBD management. Identification of...
Jeffrey R Curtis 1, Vibeke Strand 2, Steven J Golombek 3, George A Karpouzas 4 5, Lixia Zhang 6, Angus Wong 6, Krishna Patel 6, Jennifer Dines 6, Viatcheslav R Akmaev 7 Introduction: Clinical guidelines offer little guidance for treatment selection following...
John Boone, Gary Crump and Rosie Walters Introduction Step Therapy (ST), also known as “Step Edit” or “Fail First”, is a policy adopted by third-party payers to minimize costs of prescription drug use by requiring patients to trial a less expensive, first-line...
William Nowell1, Shilpa Venkatachalam2, Kelly Gavigan1, Michael George3, Johanna Withers4, Laura Stradford5, Esteban Rivera1 and Jeffrey Curtis6, 1Global Healthy Living Foundation, Upper Nyack, NY, 2Global Healthy Living Foundation, New York, NY, 3University of...
