Identifying TNFI Therapy Response in UC Patients Using Baseline Whole Blood Gene Expression Data

May 23, 2024

Shanthamallu, Uday Shankar ; Jones, Alexander ; Panés, Julián ; Corraliza Márquez, Ana Maria ; Salas, Azucena ; Akmaev, Slava ; Ghiassian, Susan Dina Background Non-response to TNF inhibitor (TNFi) therapies remains a challenge in UC/IBD management. Identification of...

Decision Impact Analysis to Measure the Influence of Molecular Signature Response Classifier Testing on Treatment Selection in Rheumatoid Arthritis

Nov 10, 2023

Jeffrey R Curtis 1, Vibeke Strand 2, Steven J Golombek 3, George A Karpouzas 4 5, Lixia Zhang 6, Angus Wong 6, Krishna Patel 6, Jennifer Dines 6, Viatcheslav R Akmaev 7 Introduction:  Clinical guidelines offer little guidance for treatment selection following...

Confronting Step Therapy in Rheumatoid Arthritis: A Rheumatology Practice’s Experience Using PrismRA to Bypass Ineffective TNF Inhibitor Therapies

Aug 30, 2023

John Boone, Gary Crump and Rosie Walters Introduction Step Therapy (ST), also known as “Step Edit” or “Fail First”, is a policy adopted by third-party payers to minimize costs of prescription drug use by requiring patients to trial a less expensive, first-line...

Patient Perceptions of Rheumatoid Arthritis Blood Work: A Cross-sectional Survey in the ArthritisPower Registry

Jun 29, 2023

William Nowell1, Shilpa Venkatachalam2, Kelly Gavigan1, Michael George3, Johanna Withers4, Laura Stradford5, Esteban Rivera1 and Jeffrey Curtis6, 1Global Healthy Living Foundation, Upper Nyack, NY, 2Global Healthy Living Foundation, New York, NY, 3University of...

Patient-Reported Outcomes in Rheumatoid Arthritis Correlate with Clinical Disease Activity Index Response in the Study to Accelerate Information of Molecular Signatures (AIMS)

Nov 14, 2022

Vibeke Strand1, Emelly Rusli2, Lixia Zhang2, Christina Le-Short2, Alix Arnaud2, Johanna Withers3 and Sam Asgarian2, 1Stanford University School of Medicine, Stanford, CA, 2Scipher Medicine Corporation, Waltham, MA, 3Scipher Medicine Corportaion, Waltham, MA...

Decreased Discontinuation and Switching of B/tsDMARD Therapy in RA Patients When Treatment Is Aligned with a Molecular Signature Response Classifier: An Analysis from the Study to Accelerate Information of Molecular Signatures (AIMS)

Nov 13, 2022

Jeffrey Curtis1, Emelly Rusli2, Lixia Zhang2, Christina Le-Short2, Alix Arnaud2, Johanna Withers3 and Sam Asgarian2, 1University of Alabama at Birmingham, Hoover, AL, 2Scipher Medicine Corporation, Waltham, MA, 3Scipher Medicine Corportaion, Waltham, MA...