Use Of The PrismRA Test To Stratify Patients For Response To Anti-TNF Therapy In RA

Oct 30, 2018

Even though there are several different therapies with different mechanism of actions, 91% of patients are prescribed anti‑TNF therapy as first-line biologic DMARD treatment Published in The Journal of Precision Medicine Authors: Keith Johnson, PhD and Michael...

PrismRA: a personalized medicine test that accurately predicts rheumatoid arthritis patients who will not respond adequately to tumor necrosis factor inhibitors

Oct 22, 2018

Keith Johnson, Nancy Schoenbrunner and Dina Ghiassian 2018 ACR/ARHP Annual Meeting Abstract: Background: Rheumatoid arthritis (RA) is a complex disease affecting about 1.3M adults in the US. The patient population is very heterogeneous; no single drug mechanism...

Khosla Ventures backs Scipher Medicine to bring precision medicine to autoimmune diseases

Sep 6, 2018

WALTHAM, Mass., Sept. 6, 2018 /PRNewswire/ — Scipher Medicine, developer of a molecular technology platform that can predict if a patient will actually respond to a particular drug therapy announced today that it has completed its Series A round led by...

Integrating personalized gene expression profiles into predictive disease-associated gene pools

Mar 13, 2017

Published in Nature: NJP Systems Biology and Applications Authors: Jörg Menche, Emre Guney, Amitabh Sharma, Patrick J. Branigan, Matthew J. Loza, Frédéric Baribaud, Radu Dobrin & Albert-László Barábasi npj Systems Biology...

Tissue Specificity of Human Disease Module

Oct 17, 2016

Maksim Kitsak1,2, Amitabh Sharma1,2,3, Jörg Menche1,2,4,5, Emre Guney1,2,6, Susan Dina Ghiassian1,2,7, Joseph Loscalzo8 & Albert-László Barabási1,2,4,7,8,9 Genes carrying mutations associated with genetic diseases are present in all human cells; yet, clinical...

Network-based in silico drug efficacy screening

Feb 1, 2016

Published in Nature Communications Authors: Emre Guney, Jörg Menche, Marc Vidal, & Albert-László Barábasi NATURE COMMUNICATIONS | 7:10331 | DOI: 10.1038/ncomms10331 |www.nature.com/naturecommunications The increasing cost of drug...

A DIseAse MOdule Detection (DIAMOnD) Algorithm Derived from a Systematic Analysis of Connectivity Patterns of Disease Proteins in the Human Interactome

Apr 8, 2015

Susan Dina Ghiassian, Jörg Menche, Albert-László Barabási PLOS Computational Biology | DOI:10.1371/journal.pcbi.1004120 April 8, 2015 Abstract The observation that disease associated proteins often interact with each other has fueled the development of network-based...

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in Asthma

Mar 21, 2015

Amitabh Sharma1,2,3,†, Jörg Menche1,2,4,8,†, C. Chris Huang5, Tatiana Ort5, Xiaobo Zhou3, Maksim Kitsak1,2, Nidhi Sahni2, Derek Thibault3, Linh Voung3, Feng Guo3, Susan Dina Ghiassian1,2, Natali Gulbahce6, Frédéric Baribaud5, Joel Tocker5, Radu Dobrin5, Elliot...

Uncovering disease-disease relationships through the incomplete interactome

Feb 20, 2015

Authors: Jörg Menche, Amitabh Sharma, Maksim Kitsak, S. Dina Ghiassian, Marc Vidal, Joseph Loscalzo, Albert-László Barabási sciencemag.org 20 FEBRUARY 2015 • VOL 347 ISSUE 6224 Introduction A disease is rarely a straightforward...

A Proteome-Scale Map of the Human Interactome Network

Nov 20, 2014

Thomas Rolland, Murat Tasxan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc...

Developing New Drug Treatments in the Era of Network Medicine

Oct 15, 2012

Published in American Society for Clinical Pharmacology & Therapeutics  Clin Pharmacol Ther. Author manuscript; available in PMC 2013 January 15.Published in final edited form as:Clin Pharmacol Ther. 2013 January ; 93(1): 26–28....