Feixiong Cheng1,2,3,4,5, István A. Kovács1,2 & Albert-László Barabási1,2,6,7 Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an important role in treating multiple complex diseases. Yet, our ability to identify and...
Boston Business Journal highlights local companies advancing healthcare using AI Artificial intelligence is changing healthcare from how we diagnose diseases, model drug development, and predict response to therapies. The Boston Business Journal names Scipher Medicine...
Scipher Medicine was featured in Technology Networks to discuss the power of RNA “Ineffective drugs have a profound impact on patients. First of all, the patient could be taking a medication that not only doesn’t make them feel better, but could also...
Published by GenomeWeb Scipher Medicine of Boston is hoping to develop molecular signatures that can predict a patient’s response to autoimmune disease drugs, pushing precision medicine into areas other than oncology. The company, which was founded in 2014 by...
Scipher Medicine Reports Positive Results for Prism, a Drug Response Test That Can Save the Health Insurance Industry $20 Billion by Avoiding Paying for Ineffective Therapies The blood test ensures patients with autoimmune diseases are prescribed the most effective...
Even though there are several different therapies with different mechanism of actions, 91% of patients are prescribed anti‑TNF therapy as first-line biologic DMARD treatment Published in The Journal of Precision Medicine Authors: Keith Johnson, PhD and Michael...
Keith Johnson, Nancy Schoenbrunner and Dina Ghiassian 2018 ACR/ARHP Annual Meeting Abstract: Background: Rheumatoid arthritis (RA) is a complex disease affecting about 1.3M adults in the US. The patient population is very heterogeneous; no single drug mechanism...
WALTHAM, Mass., Sept. 6, 2018 /PRNewswire/ — Scipher Medicine, developer of a molecular technology platform that can predict if a patient will actually respond to a particular drug therapy announced today that it has completed its Series A round led by...
Published in Nature: NJP Systems Biology and Applications Authors: Jörg Menche, Emre Guney, Amitabh Sharma, Patrick J. Branigan, Matthew J. Loza, Frédéric Baribaud, Radu Dobrin & Albert-László Barábasi npj Systems Biology...
Maksim Kitsak1,2, Amitabh Sharma1,2,3, Jörg Menche1,2,4,5, Emre Guney1,2,6, Susan Dina Ghiassian1,2,7, Joseph Loscalzo8 & Albert-László Barabási1,2,4,7,8,9 Genes carrying mutations associated with genetic diseases are present in all human cells; yet, clinical...
Susan Dina Ghiassian, Jörg Menche, Albert-László Barabási PLOS Computational Biology | DOI:10.1371/journal.pcbi.1004120 April 8, 2015 Abstract The observation that disease associated proteins often interact with each other has fueled the development of network-based...
Amitabh Sharma1,2,3,†, Jörg Menche1,2,4,8,†, C. Chris Huang5, Tatiana Ort5, Xiaobo Zhou3, Maksim Kitsak1,2, Nidhi Sahni2, Derek Thibault3, Linh Voung3, Feng Guo3, Susan Dina Ghiassian1,2, Natali Gulbahce6, Frédéric Baribaud5, Joel Tocker5, Radu Dobrin5, Elliot...
Authors: Jörg Menche, Amitabh Sharma, Maksim Kitsak, S. Dina Ghiassian, Marc Vidal, Joseph Loscalzo, Albert-László Barabási sciencemag.org 20 FEBRUARY 2015 • VOL 347 ISSUE 6224 Introduction A disease is rarely a straightforward...
Thomas Rolland, Murat Tasxan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc...
