PrismRA: a personalized medicine test that accurately predicts rheumatoid arthritis patients who will not respond adequately to tumor necrosis factor inhibitors

Oct 22, 2018

Keith Johnson, Nancy Schoenbrunner and Dina Ghiassian 2018 ACR/ARHP Annual Meeting Abstract: Background: Rheumatoid arthritis (RA) is a complex disease affecting about 1.3M adults in the US. The patient population is very heterogeneous; no single drug mechanism...

Integrating personalized gene expression profiles into predictive disease-associated gene pools

Mar 13, 2017

Published in Nature: NJP Systems Biology and Applications Authors: Jörg Menche, Emre Guney, Amitabh Sharma, Patrick J. Branigan, Matthew J. Loza, Frédéric Baribaud, Radu Dobrin & Albert-László Barábasi npj Systems Biology...

Tissue Specificity of Human Disease Module

Oct 17, 2016

Maksim Kitsak1,2, Amitabh Sharma1,2,3, Jörg Menche1,2,4,5, Emre Guney1,2,6, Susan Dina Ghiassian1,2,7, Joseph Loscalzo8 & Albert-László Barabási1,2,4,7,8,9 Genes carrying mutations associated with genetic diseases are present in all human cells; yet, clinical...

Network-based in silico drug efficacy screening

Feb 1, 2016

Published in Nature Communications Authors: Emre Guney, Jörg Menche, Marc Vidal, & Albert-László Barábasi NATURE COMMUNICATIONS | 7:10331 | DOI: 10.1038/ncomms10331 |www.nature.com/naturecommunications The increasing cost of drug...

A DIseAse MOdule Detection (DIAMOnD) Algorithm Derived from a Systematic Analysis of Connectivity Patterns of Disease Proteins in the Human Interactome

Apr 8, 2015

Susan Dina Ghiassian, Jörg Menche, Albert-László Barabási PLOS Computational Biology | DOI:10.1371/journal.pcbi.1004120 April 8, 2015 Abstract The observation that disease associated proteins often interact with each other has fueled the development of network-based...

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in Asthma

Mar 21, 2015

Amitabh Sharma1,2,3,†, Jörg Menche1,2,4,8,†, C. Chris Huang5, Tatiana Ort5, Xiaobo Zhou3, Maksim Kitsak1,2, Nidhi Sahni2, Derek Thibault3, Linh Voung3, Feng Guo3, Susan Dina Ghiassian1,2, Natali Gulbahce6, Frédéric Baribaud5, Joel Tocker5, Radu Dobrin5, Elliot...