Principal Data Scientist, Scipher Medicine Corporation, Waltham, Massachusetts

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Scipher Medicine develops innovative diagnostic tests to determine drug response and targeted therapies using its proprietary personalized medicine platform based on molecular technology. Our platform allows us to interpret genomic data to gain unique insights into disease biology so patients with even the most complex diseases can achieve optimal health outcomes.

With only about 1 out of 3 patients adequately responding to anti-tumor necrosis (anti-TNF) therapies, the world’s largest selling drug class, we developed our flagship test, PrismRA™, to predict response to these drugs, thereby ensuring patients receive the most effective therapies from day one. Scipher is transforming the traditional diagnostics business model by working closely with payers to change the way medications will be prescribed, saving both insurers and patients billions wasted in ineffective prescription costs. This is a unique opportunity to join a promising venture at an early stage to tackle some of the biggest problems in healthcare.

We are proud of our passionate, high-performance, mission-driven culture – one based on a set of values that are the cornerstone of who we are and how we hold ourselves accountable. Founded in 2015, we are based in Waltham, MA and currently expanding across all functions within the organization. We are backed by Khosla Ventures, Northpond Ventures, Alumni Ventures and Tachyon Ventures, and are well capitalized to execute our vision of launching a personalized medicine platform that transforms patients’ lives. Check us out at and follow us on LinkedIn.

The Role: The Principal Data Scientist will support the technical team to develop and apply state-of-the-art computational and statistical methods to deliver testable hypotheses and biological insights. Collaborate with other data scientists and bioinformaticians at Scipher to identify and understand complex bioinformatics analyses and information in order to translate this data into solutions.

Where: Waltham, MA

What will I do?

  • Drive the development of Scipher’s platforms and algorithms in collaboration with the research team.
  • Participate and lead components of the PRISM-RA and PRISM-UC data analysis projects.
  • Collaborate with external research organizations on Research Sponsored Agreement projects.
  • Summarize and communicate results to project teams, provide intellectual input, and contribute to decision-making.
  • Prepare and deliver scientific presentations for both internal and external use
  • Present the company’s scientific results at leading industry conferences
  • Maintain knowledge of the latest scientific and technology advancements in the field
  • Contribute to high-quality documents and scientific publications
  • Provide regular updates to the technical team
  • Manage each project within agreed upon timelines

Minimum Education and Qualifications:

This position requires a Ph.D. in Statistics, Bioinformatics, Computational Biology, Biological Science or a closely related field and 2 years of industry experience applying advanced statistical and computational methods.

Experience, which may have been gained concurrently, must include 2 years of experience with:

  • Applying principal components analysis, clustering algorithms, multi-variate regression analysis, hypothesis testing and parameter estimation to molecular and healthcare data and delivering the insight to project stakeholders;
  • Working with Bayesian Networks and Bayesian artificial intelligence including network inference, parametrization and simulation;
  • Designing and applying data science methodologies to extract, process and transform data from multiple sources;
  • Performing complex coding using R; and
  • Working with high throughput molecular data including next generation sequencing data, mass spectrometry proteomics and metabolomics data.

To all recruitment agencies: Scipher Medicine does not accept agency resumes. Please do not forward resumes to our jobs alias, or Scipher Medicine employees. Scipher Medicine is not responsible for any fees related to unsolicited resumes.

Scipher Medicine is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Scipher will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.


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